Creating of New Diagnostic and Treatment Methods by Terahertz Laser Radiation

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Important Dates

Conference:

Aug. 18-20, 2018

Full Paper Due: Jul. 20, 2018

Abstract Due: Jul. 20, 2018

Audience Registration Due:
Aug. 18, 2018

Presentations of The Int'l Symposium on Photonics and Optoelectronics (SOPO 2016)

● Creating of New Diagnostic and Treatment Methods by Terahertz Laser Radiation
Author(s)
Viacheslav Fedorov
Affiliation(s)
Institute of Laser Physics
KEYWORDS
New Diagnostic, Treatment Methods, Terahertz Laser Radiation
ABSTRACT
Creating of New Diagnostic and Treatment Methods by Terahertz Laser Radiation V.I. Fedorov Laboratory of Biophysics, Institute of Laser Physics SB RAS, Prospekt Lavrentyeva 13/3, Novosibirsk, Russia, 630090 e-mail address:vif41@mail.ru Abstract—The report emphasizes the importance of the study of terahertz radiation biological effects as another direction in the creation of diagnostic and therapeutic methods, along with terahertz imaging and terahertz spectroscopy. Therapeutic and diagnostic use of laser terahertz radiation based on the results of pre-conducted fundamental research of biological effects of terahertz radiation at the organismic, cellular and molecular levels presents. Keywords—terahertz radiation; biologic effects; treatment; diagnostics. I. TREATMENT The investigation of terahertz effects on organism level lets to use the terahertz radiation as treatment factor. It was demonstrated the dose-dependent influence of terahertz radiation on rat spleen cell production of antibodies to sheep red blood cells and on migration ability of B-lymphocytes in antigen presence. In addition it was demonstrated the dose-dependent influence of THz radiation on stage of bone regeneration in rats with experimental defect of femur. These results allowed to use the gas-discharge HCN laser (0,89 THz) for treatment traumatic and degenerative disorders in bone and cartilage tissues. Treatment of rats with experimental mechanical damage to the skin demonstrates the decrease in wound area. Terahertz irradiation of patients with post-operative and post-traumatic mechanical skin lesions demonstrates the next results of treatment: the acceleration of wound healing, the prevention of post-operative and post-traumatic suppuration of wounds, the increase in contraction of wound surface, the stimulation of regenerative ability and optimization of cellular composition of wound exudate. Terahertz irradiation of volunteers with spinal osteochondrosis induces positive dynamics of metabolism indices in the cartilage (normalization of chondroitin sulfate and glycosaminoglycans serum levels). Experimental treatment of grafted Guerin carcinoma by terahertz radiation demonstrates the reduction of tumor growth.. Degree of tumor growth reduction after terahertz treatment and x-rays treatment are identical. II. DIAGNOSTICS Terahertz radiation causes more pronounced increase of mitogen-induced proliferation of lymphocytes. It was found that among healthy persons there are the individuals with initially low proliferative activity of lymphocytes. Responses of lymphocytes to terahertz irradiation were different. There is or the absence of proliferous potential ability or pronounced proliferous potential ability. In the first case there is an insufficiency of immune system , in the second case – the lesion of regulation of immune system. It may be used at asymptomatic and early stages of different diseases, which induced by immune insufficiency: all diseases of internal organs, oncologic diseases, autoimmune diseases etc. It can be a base for creating the diagnostic test to evaluate the ability of lymphocytes to proliferation and apply it to identify individuals at the early stages of different diseases, which induced by immune insufficiency: all diseases of internal organs, different hematological diseases, oncologic diseases, autoimmune diseases etc. This may facilitate the identification of trends to failure of the immune system in healthy individuals. It was demonstrated that terahertz radiation results in a viability reduction in part of irradiated lymphocytes. This is tested by the appearance in cytoplasm the colorant penetrating only nonviable cells. Based on this result it is possible to create the diagnostic test for identifying of potentially nonviable lymphocytes and used it to identify healthy individuals which have the early stages of various hematological disorders, different variations of immune system disturbance and other diseases that lead to such violations. Terahertz radiation induces a specific state, which in combination with provoking factor reveals to morphological or functional abnormalities which are undiagnosable by traditional methods. The study of terahertz radiation influence on membrane stability of red blood cells demonstrates that terahertz radiation does not influence spontaneous hemoglobin output, but increases the hemoglobin output induced by water adding to isotonic buffer solution (hypoosmotic hemolysis). This effect is increased if the concentration of sodium chloride solution is decreased. Terahertz radiation causes pronounced shorting of duration of full hypoosmotic hemolysis. Results of these experiments can be a premise for creating the diagnostic test for identifying a tendency to disturbance of red blood cell membrane resistance in healthy individuals for recognition of early stage of various hematological, nephrological, endocrinological and other diseases which are associated with impaired membrane status of these cells.